منابع مشابه
Regulating renal drug elimination?
A mong the clinically highly relevant functions of the kidney is the elimination of xenobiotics, including drugs. In the past years a wide variety of transport systems have been identified serving renal transport of organic cations and anions (1–4). The operation of several of those transport proteins and the partially poor substrate selectivity allows the kidneys to efficiently eliminate a mul...
متن کاملDrug Elimination and Clearance
Drug elimination is described in terms of clearance from a well-stirred compartment containing uniform drug distribution. The term clearance describes the process of drug elimination from the body or from a single organ without identifying the individual processes involved. Clearance may be defined as the volume of fluid cleared of drug from the body per unit of time. The units for clearance ar...
متن کاملThe Renal Elimination of Bilirubin
The elimination of bile pigment during jaundice is, for practical purposes, unincreased by diuresis from water by mouth. Possibly, though, the flushing of the kidneys tends to lessen pigment accumulation within these organs and thus to diminish a serious potential source of trouble in long continued jaundice. Flood diuresis from intravenous injections of salt solution markedly increases the out...
متن کاملInfluence of cancer cachexia on drug liver metabolism and renal elimination in rats
BACKGROUND Body wasting and cachexia change body composition and organ function, with effects on drug pharmacokinetics. The aim of this study was to investigate how cancer and cancer cachexia modify liver metabolism and renal drug elimination in rats. METHODS Nine male Wistar-Han rats received a single oral dose of midazolam and propranolol (markers of hepatic metabolism), and 10 rats receive...
متن کاملHomeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination.
This review attempts to summarize and clarify our basic knowledge as to the various factors that potentially influence the risks imposed from chronic exposure to high atmospheric levels of manganese (Mn). The studies describe the interrelationship of the different systems in the body that regulate Mn homeostasis by characterizing specific, biological components involved in its systemic and cell...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2005
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2005030311